The Sierra is built on a stiff platform for a smooth ride and sharp handling. The GMC Sierra shares platforms with the Chevy Silverado but its exterior styling is quite different. Sierra interiors offer a choice of two dashboard styles.

The 2008 GMC Sierra is offered in a Denali version, which makes for a comfortable, luxurious, pickup with the emphasis on performance rather than payload and towing capacity. The Sierra Denali offers the same sort of higher-line content as GMC's upscale Yukon Denali sport utility.

Amongst the various cab styles, bed lengths, and eight engine choices (of five sizes) the Sierra offers many permutations. There are limitations however, such as the biggest engine is limited to the Denali, the 6-liter does not go in regular cab or extended cab long bed trucks, and manual transmissions are not offered.