A 5.4-liter V8 with 300 horsepower and 365 pound-feet of torque is standard on all models up to the F-350 Crew Cab DRW, which has the 362-hp, 457 lb-ft 6.8-liter V10 standard. Both the V10 and 6.4-liter diesel (350 hp, 650 lb-ft) are optional across the F-250/F-350 spectrum, but the diesel is the only engine offered on F-450. A six-speed manual is standard, a five-speed automatic available.

The base XL is commercial in nature, with vinyl seats and flooring, black painted grille and bumpers, plain trim, AM/FM stereo, and a weight-appropriate receiver hitch. Options include mechanical upgrades (engine, limited-slip differential, larger tires, traction control, camper package, off-road package for 4WD, Tow Command, etc.), air conditioning, auxiliary switches, reverse sensors, and a tailgate step.

XLT trim adds chrome trim and wheels, 40/20/40 cloth front seat, carpet, AC, CD player, power windows/locks/mirrors, tilt wheel and cruise control. Options include aluminum wheels, captain's chairs w/power and heat, Audiophile sound system, adjustable pedals, Sport trim package, moonroof, and rear-seat DVD entertainment.

The FX4 off-road model adds 18-inch wheels and LT275/70R18 all-terrain tires, standard limited-slip, skid plates, fog lamps, security system, overhead console, and leather-wrapped steering wheel. Options include 20-inch wheels, navigation/Audiophile system, Sirius radio, and power telescope/fold heated dual-element towing mirrors.

Lariat trim (n/a on regular cabs) adds polished wheels, leather power seats, dual-zone climate control, trip computer, redundant sound/climate controls on wheel, woodgrain trim, illuminated visor mirrors, privacy glass and a sliding rear window. Options include those offered on most Super Duty models plus captain's chairs, universal door opener, and a power sliding rear window.

The King Ranch package, offered only on Lariat Crew Cabs, adds two-tone paint, driver memory package, tow mirrors, unique forged alloy wheels, powered trailer mirrors, badging, and Chaparral-leather for the steering wheel and four captain's chairs and both center consoles.

Safety equipment includes antilock brakes, dual front airbags, adjustable height outboard belt anchors, child-seat LATCH anchors, and a passenger airbag deactivation switch on regular and SuperCabs, all standard.