The Vue is a bit larger than both the Ford Escape and Honda CR-V, as the Saturn's 106.6-inch wheelbase is some three inches longer. This dimension gives the Vue a useful advantage in passenger volume, as it offers 113.0 cubic feet of passenger space compared to the Escape's 99.2 cubic feet and CR-V's 103.8 cubic feet.

The Vue compromises its cargo volume slightly in the process, however, as it has 30.8 cubic feet of cargo volume with the second seat in place, and 63.8 cubic feet of cargo volume when the second seat is folded flat. In comparison, the Escape offers 29.3 cubic feet and 66.3 cubic feet respectively, while the CR-V has 35.7 feet and 72.9 cubic feet respectively.

The Vue weighs as much as a mid-size car, ranging between the 3292 pounds of the Vue four-cylinder with manual transmission to the 3668 pounds of the Vue V-6. An Escape averages about 150 pounds lighter, while the CR-V is about 100 pounds heavier. Like the CR-V, the four-cylinder Vue can tow 1500 pounds, and like an Escape V-6, the Vue V-6 can tow 3500 pounds.

The Vue looks practical, not cute. A major makeover for the 2006 model year added new front and rear fascias, and there's more style overall than before. The high beltline is fashionable, but compromises visibility for kids sitting in the back seat. The one-piece rear liftgate is complemented by a low bumper with an integrated step pad, affording easier loading into the cargo area.

For 2007, standard wheel sizes have been upgraded to 16 inches for four-cylinder models and 17 inches for V6 models.

One important feature of the Saturn Vue is the use of polymer (plastic) body panels for the exterior. This dent-resistant construction has long been a part of Saturn's philosophical emphasis on practicality and durability. Unfortunately there's a downside to this feature, as the gaps between the body panels are a little large and unsightly, and there seems to be some shake and rattle of the panels as well.